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The immune microenvironment in maternal-fetal interface contributes to the parturition and preterm labor

YUAN Jian-Qiang¹, WANG Yuan-Chen¹, WANG Zhi-Ming¹, LI Li², GAO Lu^1,*

¹Department of Physiology, Naval Medical University, Shanghai 200433, China；²Department of Obstetrics and Gynecology, Changhai Hospital, Naval Medical University, Shanghai 200433, China

Abstract

The maintenance of human pregnancy and the initiation of parturition are closely related with the dynamic balance of the maternal-fetal immune microenvironment. Implantation of the blastocyst into the maternal decidua is the first step in pregnancy establishment, which is favored by the abundant blood flow and the immunotolerant microenvironment maintained by the balance of immune cells. The parturition resembles an inflammatory response that includes secretion of cytokines by resident and infiltrating immune cells into reproductive tissues and the maternal-fetal interface, which promotes the delivery of fetus from maternal organism. Therefore, the immune microenvironment in maternal-fetal interface regulates the critical steps of pregnancy and parturition. When the maternal-fetal immune microenvironment is imbalanced or impaired, miscarriage or preterm labor would happen. This article reviews the roles and mechanisms of several important immune cells in the maternal-fetal interface during the parturition and preterm labor.

Key words: Pregnancy; parturition; maternal-fetal interface; immune microenvironment; preterm labor

Received: 2019-07-24　　Accepted: 2019-10-29

Corresponding author: 高路　　E-mail: roadgao@163.com

DOI: 10.13294/j.aps.2019.0084

Citing This Article：

YUAN Jian-Qiang, WANG Yuan-Chen, WANG Zhi-Ming, LI Li, GAO Lu. The immune microenvironment in maternal-fetal interface contributes to the parturition and preterm labor. Acta Physiol Sin 2020; 72 (1): 1-10 (in Chinese with English abstract).