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Research advances in relationship between biological clock and cardiovascular diseases

JIANG Ting-Ting¹, JI Shuang¹, YANG Guang-Rui², CHEN Li-Hong^1,*

¹Advanced Institute for Medical Sciences, Dalian Medical University, Dalian 116044, China；²School of Bioengineering, Dalian University of Technology, Dalian 116044, China

Abstract

Circadian rhythms widely exist in living organisms, and they are regulated by the biological clock. Growing evidence has shown that circadian rhythms are tightly related to the physiological function of the cardiovascular system, including blood pressure, heart rate, metabolism of cardiomyocytes, function of endothelial cells, and vasoconstriction and vasodilation. In addition, disruption of circadian rhythms has been considered as one of the important risk factors for cardiovascular diseases, such as myocardial infarction. This review summarizes the recent research advances in the relationship between circadian clock and cardiovascular diseases, hoping to improve treatment strategies for patients with cardiovascular diseases according to the theory of biological clock.

Key words: biological clock; circadian rhythms; cardiovascular disease; myocardial infarction; atherosclerosis; hypertension

Received: 2019-01-21　　Accepted: 2019-05-15

Corresponding author: 陈丽红　　E-mail: bjclh2000@163.com

DOI: 10.13294/j.aps.2019.0066

Citing This Article：

JIANG Ting-Ting, JI Shuang, YANG Guang-Rui, CHEN Li-Hong. Research advances in relationship between biological clock and cardiovascular diseases. Acta Physiol Sin 2019; 71 (5): 783-791 (in Chinese with English abstract).