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Involvement of intrathecal activation of MrgC receptor in pathological pain and morphine tolerance

LI You-Ping*, JIANG Jian-Ping

College of Life Sciences, Fujian Normal University, Fujian Key Laboratory of Developmental and Neuro Biology, Fuzhou 350117, China

Abstract

Rodent MrgC receptor (Mas-related G-protein-coupled receptor subtype C) shares 65% sequence homology and similarities in terms of expression pattern and binding profile with human Mas-related gene X receptor 1 (hMrgX1). Therefore, researchers generally explore the role of hMrgX1 by studying the function of MrgC receptor. Murine MrgC receptor is uniquely expressed in small-diameter neurons of dorsal root ganglia (DRG) and trigeminal ganglia (TG), which is closely related to the transmission process of pain. This review summarizes the analgesic effects of intrathecal activation of MrgC receptors in pathological pain and morphine tolerance.


Key words: human Mas-related gene X receptor 1; Mas-related G-protein-coupled receptor subtype C; dorsal root ganglion; spinal dorsal horn; pathological pain; morphine tolerance

Received: 2018-12-09  Accepted: 2019-01-14

Corresponding author: 李幼萍  E-mail:

DOI: 10.13294/j.aps.2019.0031

Citing This Article:

LI You-Ping, JIANG Jian-Ping. Involvement of intrathecal activation of MrgC receptor in pathological pain and morphine tolerance. Acta Physiol Sin 2019; 71 (5): 741-748 (in Chinese with English abstract).