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Research progress on neural mechanism of peripheral inflammation in Parkinson’s disease 

LIU Yong-Ting¹, SUN Ming-Hao¹, CAI Chun-Wei¹, REN Chao², NIU Hai-Chen^3,*

¹Department of Clinical Medicine, Xuzhou Medical University, Xuzhou 221004, China；²Department of Neurology, Yantai Yuhuangding Hospital, Qingdao University, Yantai 264000, China; 3Department of Genetics, Xuzhou Medical University, Xuzhou 221004, China；³Department of Genetics, Xuzhou Medical University, Xuzhou 221004, China

Abstract

Parkinson’s disease (PD) is the second most common neurodegenerative disease, characterized by loss of dopaminergic (DA) neurons in the dense part of the substantia nigra (SNpc). Postmortem analysis of PD patients and experimental animal studies found that microglial cell activation and increased levels of pro-inflammatory factors were common features of PD brain tissue. At the same time, the invasion and accumulation of peripheric immune cells were detected in the brain of PD patients. In this paper, peripheral inflammation across the blood-brain barrier (BBB), the misfolded α-synuclein (α-syn)-induced microglial cell activation and intracerebral inflammation in PD are summarized, providing potential therapeutic measures for delaying the onset of PD.

Key words: Parkinson’s disease; peripheral inflammation; α-synuclein; blood-brain barrier; microglial cell

Received: 2019-02-23　　Accepted: 2019-05-20

Corresponding author: 牛海晨　　E-mail: nhcnhc@163.com

DOI: 10.13294/j.aps.2019.0053

Citing This Article：

LIU Yong-Ting, SUN Ming-Hao, CAI Chun-Wei, REN Chao, NIU Hai-Chen. Research progress on neural mechanism of peripheral inflammation in Parkinson’s disease . Acta Physiol Sin 2019; 71 (5): 732-740 (in Chinese with English abstract).