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Research progress of mast cell activation-related receptors and their functions

JIANG Yu-Cui¹, YE Fan², DU Ying¹, TANG Zong-Xiang^1,*

¹Department of Physiology, School of Medicine and Life Sciences, Nanjing University of Chinese Medicine, Nanjing 210023, China；²Department of Biological Sciences, School of Biological Resources and Environmental Sciences, Jishou University, Jishou 416000, China

Abstract

Mast cells are widely distributed in various parts of the body, especially in the mucosal surface between the body and the external environment. Mast cell is one of the important immune cells and plays important roles in innate immunity, adaptive immunity and immune regulation. Previous researches have shown that excessive activation of mast cells is closely related to the development of allergic and inflammatory diseases such as asthma, allergic rhinitis, food allergies, acute and chronic itching. Mast cells infiltrate into the inflammation site and release various allergic mediators during the occurrence and development of these diseases. Therefore, termination of mast cell activation can be one of the effective methods for the treatment of allergic and inflammatory diseases, and receptors related to mast cell activation are potential targets for the development of anti-allergic drugs. There are many receptors related to mast cell activation, and the effects mediated by different receptors varied from each other. In the recent years, new mast cell receptors are being discovered, but there are not many literatures discussing the possible functions of these newly discovered receptors. This review aims to summarize the receptors involved in mast cell activation and classify related receptors according to their effects. 

Key words: mast cells; receptors; function; signaling pathway

Received: 2018-09-11　　Accepted: 2018-11-19

Corresponding author: 唐宗湘　　E-mail: zongxiangtang@njucm.edu.cn

DOI: 10.13294/j.aps.2019.0042

Citing This Article：

JIANG Yu-Cui, YE Fan, DU Ying, TANG Zong-Xiang. Research progress of mast cell activation-related receptors and their functions. Acta Physiol Sin 2019; 71 (4): 645-656 (in Chinese with English abstract).