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Research advances in relationship between mitochondrial dynamics and cellular energy metabolism and exercise intervention

ZHAO Yong-Cai¹, GAO Bing-Hong^2,*

¹Graduate School, Shanghai University of Sport, Shanghai 200438, China；²School of Physical Education and Sport Training, Shanghai University of Sport, Shanghai 200438, China

Abstract

Mitochondrial dynamics, involving mitochondrial fusion, fission and autophagy, plays an important role in maintaining cellular physiological function and homeostasis. Mitochondria are the “energy plant” of human body, so the changes of mitochondrial 

fusion, division and autophagy are important for cell respiration and energy production. On the other hand, energy metabolism influences mitochondrial dynamics in turn. This paper reviewed the recent advances in studies on the relationship between energy metabolism and the proteins regulating mitochondrial fusion, fission and autophagy. The association of mitochondrial dynamics with electron chain complex expression, oxidative phosphorylation and ATP synthesis upon exercise intervention will provide theoretical references for the further studies in sports training and disease intervention.

Key words: Exercise; oxidative phosphorylation; mitochondrial fusion; mitochondrial fission; mitophagy

Received: 2018-09-28　　Accepted: 2018-12-03

Corresponding author: 高炳宏　　E-mail: gaobinghong@126.com

DOI: 10.13294/j.aps.2019.0037

Citing This Article：

ZHAO Yong-Cai, GAO Bing-Hong. Research advances in relationship between mitochondrial dynamics and cellular energy metabolism and exercise intervention. Acta Physiol Sin 2019; 71 (4): 625-636 (in Chinese with English abstract).