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Mechanisms of adiponectin protection against diabetes-induced vascular endothelial injury 

DU Yun-Hui, MA Xin-Liang^*

Beijing Institute of Heart, Lung and Blood Vessel Diseases, Beijing Anzhen Hospital, Capital Medical University, Beijing 100029, China

Abstract

The incidence and mortality rates of diabetes with cardiovascular complications are continually rising, and diabetic cardiovascular disease is becoming a major public health issue that threatens human health. Acute endothelial dysfunction and chronic cellular damage caused by diabetes are important risk factors for diabetic cardiovascular disease and related mortality. Adiponectin is an adipocyte-derived molecule with significant cytoprotective effects, including the protection against diabetes-induced vascular endothelial injury. Here we review the mechanisms of adiponectin protective effects on acute vascular endothelial dysfunction and chronic structural damage induced by diabetes.

Key words: adiponectin; vascular endothelial protection; mechanism

Received: 2018-08-21　　Accepted: 2018-10-16

Corresponding author: 马新亮　　E-mail: xinma2006@gmail.com

DOI: 10.13294/j.aps.2019.0041

Citing This Article：

DU Yun-Hui, MA Xin-Liang. Mechanisms of adiponectin protection against diabetes-induced vascular endothelial injury . Acta Physiol Sin 2019; 71 (3): 485-490 (in Chinese with English abstract).