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The cardiovascular protection of irisin and its research progress in sports field

WANG Shen¹, LIAO Jing-Wen², YIN Hong-Gang², JI Hui-Hui³, YU Hang³, ZOU Yu-Hao³, HU Min^2,*

¹Department of Sports and Health, Guangzhou 510500, China；²Scientific Research Center, Guangzhou Sport University, Guangzhou 510500, China；³Medical School of Ningbo University, Ningbo 315000, China

Abstract

Irisin is a circulating myokine induced by exercise, which is a cleaved version of fibronectin type III domain containing protein 5 (FNDC5). It can promote the browning of white fat tissue, increase energy consumption, and decrease weight. Irisin plays an important role in the regulation of various diseases, such as diabetes and coronary heart disease. Different types of exercise have different effects on irisin level in blood circulation, and moderate exercise can reduce cardiovascular symptoms. In this paper, the cardiovascular protective effect of irisin and its research progress in the field of exercise are reviewed, hoping to provide a new target for the prevention and treatment of cardiovascular diseases.

Key words: irisin; cardiovascular disease; exercise; endothelial dysfunction

Received: 2018-06-29　　Accepted: 2018-12-23

Corresponding author: 胡敏　　E-mail: whoomin@aliyun.com

DOI: 10.13294/j.aps.2019.0032

Citing This Article：

WANG Shen, LIAO Jing-Wen, YIN Hong-Gang, JI Hui-Hui, YU Hang, ZOU Yu-Hao, HU Min. The cardiovascular protection of irisin and its research progress in sports field. Acta Physiol Sin 2019; 71 (3): 478-484 (in Chinese with English abstract).