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Research advances in endogenous neural stem cells promoting neural repair after ischemic stroke

FANG Chang-Yun¹, WU Xu-Sheng¹, ZHANG Hang¹, GU Yan-Ling¹, WANG Shi-Bing¹, REN Hui-Wen¹, CHEN Ke¹, ZHANG Hui², CHENG Bao-Hua², GAO Yang^2,*

¹School of Clinical Medicine, Jining Medical University, Jining 272067, China；²College of Basic Medical Sciences, Jining Medical University, Jining 272067, China

Abstract

Neural stem cell therapy, as a new therapeutic method for neural diseases, has aroused a wide concern for over 20 years since neural stem cells were first found in 1992. Ischemic stroke is highly concerned because of its high incidence, mortality and disability rates. Because the brain has a limited ability to repair itself, to improve neural function and promote neural regeneration may help to prevent occurrence and development of neurological diseases. It is noteworthy that some stroke patients showed an ability to repair brain several months after the stroke happened, suggesting an existence of endogenous nerve repair in these patients. The research advances in functions of endogenous neural stem cells in neural regeneration and the related regulators after ischemic stroke are summarized in this review to provide new views of the mechanism of neural functional recovery after ischemic stroke.

Key words: ischemic stroke; endogenous neural stem cells; neural regeneration; research progress

Received: 2018-08-11　　Accepted: 2018-10-08

Corresponding author: 高洋　　E-mail: gyjnmc2017@yeah.net

DOI: 10.13294/j.aps.2019.0035

Citing This Article：

FANG Chang-Yun, WU Xu-Sheng, ZHANG Hang, GU Yan-Ling, WANG Shi-Bing, REN Hui-Wen, CHEN Ke, ZHANG Hui, CHENG Bao-Hua, GAO Yang. Research advances in endogenous neural stem cells promoting neural repair after ischemic stroke. Acta Physiol Sin 2019; 71 (3): 454-462 (in Chinese with English abstract).