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Different types of molecular hydrogen donors and their pharmacokinetics in vivo

LIU Bo-Yan^*, QIN Shu-Cun

Key Laboratory of Atherosclerosis in Universities of Shandong Province, Institute of Atherosclerosis, Taishan Medical University, Taishan Institute for Hydrogen Biomedical Research, Taian 271000, China

Abstract

Molecular hydrogen (H2) has been shown to have diverse biomedical effects. As a small molecular gas, hydrogen can be diffused to the target without hindrance. A variety of related hydrogen products used in medical research and public health have been developed. There are various methods of administration of H2, mainly including inhaling hydrogen gas, drinking hydrogen water, injecting hydrogen-saline, orally taking solid-state H2 sustained-release agents, and stimulating intestinal microbiomes to produce hydrogen. Pharmacokinetics of H2 in vivo vary with methods of administration and thus influence its biomedical effects. This review summarizes the types of H2 donors and their pharmacokinetics in vivo.

Key words: molecular hydrogen (H2); pharmacokinetics; administration of H2

Received: 2018-04-11　　Accepted: 2018-06-25

Corresponding author: 刘伯言　　E-mail: scqin@tsmc.edu.cn

DOI: 10.13294/j.aps.2018.0083

Citing This Article：

LIU Bo-Yan, QIN Shu-Cun. Different types of molecular hydrogen donors and their pharmacokinetics in vivo. Acta Physiol Sin 2019; 71 (2): 371-377 (in Chinese with English abstract).