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Role of prostaglandin E2 receptor 4 in cardiovascular diseases

WANG Sai-Lun¹, LU Jia-Wei², GUAN You-Fei¹, ZHANG Xiao-Yan¹, XU Hu^1,*

¹dvanced Institute for Medical Sciences, Dalian Medical University, Dalian 116044, China；²Department of Orthopaedics, First Affiliated Hospital, Dalian Medical University, Dalian 116011, China

Abstract

Prostaglandin E2 (PGE2) is a cyclooxygenase metabolite of arachidonic acid. It acts as a bioactive lipid and plays an important role in regulating many biological processes. PGE2 binds to 4 different G protein-coupled receptors including prostaglandin E2 receptor subtypes EP1, EP2, EP3 and EP4. The EP4 receptor is widely expressed in most of human organs and tissues. Increasing evidence demonstrates that EP4 is essential for cardiovascular homeostasis and participates in the pathogenesis of many cardiovascular diseases. Here we summarize the role of EP4 in the regulation of cardiovascular function and discuss potential mechanisms by which EP4 is involved in the development of cardiovascular disorders with a focus on its effect on inflammation.

Key words: prostaglandin E2; EP4; signal transduction; inflammation; cardiovascular disease

Received: 2018-05-15　　Accepted: 2018-09-25

Corresponding author: 徐虎　　E-mail: xuhu1024@126.com

DOI: 10.13294/j.aps.2019.0011

Citing This Article：

WANG Sai-Lun, LU Jia-Wei, GUAN You-Fei, ZHANG Xiao-Yan, XU Hu. Role of prostaglandin E2 receptor 4 in cardiovascular diseases. Acta Physiol Sin 2019; 71 (2): 361-370 (in Chinese with English abstract).