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Facilitative glucose transporters: expression, distribution and the relationship to diseases 

WEI Lan-Lan¹, REN Xu², ZHAO Yan-Yan¹, WANG Li², ZHAO Yu-Feng^1,*

¹Institute of Basic Medical Sciences, Xi’an Medical University, Xi’an 710021, China；²Department of Nephrology, The Second Affiliated Hospital of Medical School, Xi’an Jiao Tong University, Xi’an 710004, China

Abstract

Facilitative glucose transporters (GLUT) are proteins that mediate glucose transmembrane transport in the form of facilitated diffusion, which play an important role in regulating cell energy metabolism. There are many breakthroughs in researches of facilitative GLUT in recent years. It has been known that there are 14 subtypes of facilitative GLUT with obvious tissue specificity in distribution and physiological function. In the present review, the tissue and cellular distribution, subcellular localization, expression regulation, physiological function and the relationship to diseases of facilitative GLUT subtypes were summarized, in order to further understand their physiological and pathophysiological significances.

Key words: facilitative glucose transporters; tissue distribution; expression regulation; physiological function

Received: 2018-06-09　　Accepted: 2018-09-12

Corresponding author: 赵玉峰　　E-mail: yufeng.zhao@xiyi.edu.cn

DOI: 10.13294/j.aps.2018.0084

Citing This Article：

WEI Lan-Lan, REN Xu, ZHAO Yan-Yan, WANG Li, ZHAO Yu-Feng. Facilitative glucose transporters: expression, distribution and the relationship to diseases . Acta Physiol Sin 2019; 71 (2): 350-360 (in Chinese with English abstract).