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Cancer pain, a serious threat to patients

OUYANG Xue-Yan¹, YANG Chao², ZHU Zhen³, LI Jing¹, SUN Yun-Heng¹, DING Gang⁴, JI Yong-Hua³, JIANG Feng^2,*

¹Oncology Department, Xinhua Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai 200092, China；²Scientific Research Management Department, Xinhua Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, Chongming Branch, Shanghai 202150, China；³Xinhua Translational Institute for Cancer Pain, Shanghai 202150, China；⁴Oncology Department, Shanghai International Medical Center, Shanghai 201318, China

Abstract

A large number of cancer patients suffer from pain. Growing evidence suggested that pain might be a serious risk factor for cancer patients. The shared modulators and modulation pathways between neural system and tumor cells, such as various neurotransmitters and neurogenic cytokines, provide essential basis for the effect of pain on tumor. In this article, we reviewed some possible mechanism of this process from two aspects: the systematic regulation of central nervous system on endocrine and immunity, and the regional regulation of peripheral nerves on tumor cells. The aim of this review is to provide more innovative knowledge about pain and cancer and to emphasize the importance of anti-pain in the therapy of cancer.

Key words: Pain; tumor; neuro-endocrine-immune regulation

Received: 2018-05-04　　Accepted: 2018-12-14

Corresponding author: 姜峰　　E-mail: jf365321@163.com

DOI: 10.13294/j.aps.2019.0022

Citing This Article：

OUYANG Xue-Yan, YANG Chao, ZHU Zhen, LI Jing, SUN Yun-Heng, DING Gang, JI Yong-Hua, JIANG Feng. Cancer pain, a serious threat to patients. Acta Physiol Sin 2019; 71 (2): 343-349 (in Chinese with English abstract).