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Modulation of drug-metabolizing enzymes and transporters under hypoxia environment

MIN Qiong^1,2, FENG Shi-Lan¹, LU Hui², LI Wen-Bin², WANG Chang², ZHANG Juan-Hong², WANG Rong^1,2,*

¹College of Pharmacy, Lanzhou University, Lanzhou 730000, China；²Key Laboratory of the Plateau Environmental Damage Control, Lanzhou General Hospital of Lanzhou Military Command, PLA, Lanzhou 730050, China

Abstract

Drug metabolism is significantly affected under hypoxia environment with changes of pharmacokinetics, expression and function of drug-metabolizing enzymes and transporters. Studies have shown that hypoxia increases the release of a series of inflammatory cytokines which can modulate drug metabolism. Besides, both hypoxia inducible factor 1α (HIF-1α) and microRNA-mediated pathways play a role in regulating drug metabolism. This article reviewed the impact and single-factor modulating mechanisms of drug metabolism under hypoxia, and put forward the speculation and prospects of multi-factor modulating mechanisms.

Key words: Hypoxia; drug-metabolizing enzymes; transporters; modulating mechanism

Received: 2018-04-19　　Accepted: 2018-08-10

Corresponding author: 王荣　　E-mail: wangrong-69@163.com

DOI: 10.13294/j.aps.2018.0082

Citing This Article：

MIN Qiong, FENG Shi-Lan, LU Hui, LI Wen-Bin, WANG Chang, ZHANG Juan-Hong, WANG Rong. Modulation of drug-metabolizing enzymes and transporters under hypoxia environment. Acta Physiol Sin 2019; 71 (2): 336-342 (in Chinese with English abstract).