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Advances on the anti-inflammatory and protective effect of AMPK activators

PENG Xian-Wen¹, ZHOU Hong-Hong¹, DAI Jie², ZHANG Li^1,3,*

¹Department of Pathophysiology, Chongqing Medical University, Chongqing 400016, China；²Hospital of Chongqing University of Arts and Sciences, Chongqing 402160, China；³Laboratory of Stem Cell and Tissue Engineering, Chongqing Medical University, Chongqing 400016, China

Abstract

AMP-activated protein kinase (AMPK) is a key enzyme in the regulation of cellular energy homeostasis. Recent studies demonstrated that AMPK also plays an important role in the modulation of inflammation, an energy-intensive molecular response. The commonly used AMPK activators include 5-aminoimidazole-4-carboxamide ribonucleotide (AICAR) and A-769662. In addition, the biological activities of metformin and adiponectin are closely related to activation of AMPK. Numerous studies have shown that these AMPK activators play an effectively protective role in animal models of acute lung injury, asthma, colitis, hepatitis, atherosclerosis and other inflammatory diseases. Therefore, AMPK activators may have promising potential for the prevention and treatment of inflammation related diseases.

Key words: AMP-activated protein kinase; AICAR; A-769662; metformin; adiponectin

Received: 2018-04-21　　Accepted: 2018-09-12

Corresponding author: 张力　　E-mail: zhangli@cqmu.edu.cn

DOI: 10.13294/j.aps.2018.0094

Citing This Article：

PENG Xian-Wen, ZHOU Hong-Hong, DAI Jie, ZHANG Li. Advances on the anti-inflammatory and protective effect of AMPK activators. Acta Physiol Sin 2019; 71 (2): 319-326 (in Chinese with English abstract).