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Molecular mechanism of vascular remodeling in hypertension and Chinese medicine intervention

ZHANG Chan-Juan^1,2, SHI Ya-Ning^1,2, LIAO Duan-Fang², DU Ke¹, QIN Li^1,2,*

¹Department of Pharmacology, School of Pharmacy, Changsha 410208, China；²Division of Stem Cell Regulation and Application, Hunan University of Chinese Medicine, Changsha 410208, China

Abstract

Vascular remodeling is a significant pathological characteristic of hypertension, which is regulated by complex regulatory networks. The vascular remodeling may be adaptive initially, however it becomes maladaptive and decompensation eventually and further compromises target organ function, leading to hypertensive cardiovascular complications. This review focuses on the role and mechanisms of vascular remodeling in the pathogenesis and progression of hypertension and its complications. Moreover, the strategies of syndrome differentiation of traditional Chinese medicine application provide clinical and theoretical evidences for hypertensive vascular remodeling therapy. A better understanding of underlying signaling pathways, therapeutic targets in vascular remodeling, as well as screening of active ingredients from traditional Chinese medicine may be able to provide some effective approaches for vascular protection in hypertensive diseases.

Key words: vascular remodeling; hypertension; traditional Chinese medicine; molecular mechanism

Received: 2018-06-28　　Accepted: 2018-12-23

Corresponding author: 覃丽　　E-mail: lqin1011@126.com

DOI: 10.13294/j.aps.2019.0014

Citing This Article：

ZHANG Chan-Juan, SHI Ya-Ning, LIAO Duan-Fang, DU Ke, QIN Li. Molecular mechanism of vascular remodeling in hypertension and Chinese medicine intervention. Acta Physiol Sin 2019; 71 (2): 235-247 (in Chinese with English abstract).