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Urinary biomarkers for chronic kidney disease: a focus on gene transcript

LYU Lin-Li, LIU Bi-Cheng^*

Institute of Nephrology, Zhongda Hospital, Southeast University, Nanjing 210009, China

Abstract

Chronic kidney disease (CKD) is becoming an alarming health burden worldwide, however, there is still lack of early     biomarkers and effective treatment options. Thus, in the upcoming era of precision medicine, searching for the sensitive, non-invasive biomarkers has been the cornerstone and major challenge in the management of CKD. Urine contains rich biological information which could be an ideal source for non-invasive biomarkers of CKD. This review will discuss the recent advances in biomarker study from urine sediment, urine supernatant and urinary extracellular vesicles with special interest in gene transcript (miRNA, mRNA) biomarkers. Besides, the challenges and future directions for urinary gene transcript biomarker study will be discussed.  

Key words: urine; biomarkers; chronic kidney disease; extracellular vesicle; gene transcript

Received: 2018-06-05　　Accepted: 2018-10-11

Corresponding author: 刘必成　　E-mail: liubc64@163.com

DOI: 10.13294/j.aps.2018.0070

Citing This Article：

LYU Lin-Li, LIU Bi-Cheng. Urinary biomarkers for chronic kidney disease: a focus on gene transcript. Acta Physiol Sin 2018; 70 (6): 644-648 (in Chinese with English abstract).