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Research update of Klotho in kidney injury and repair

DAI Hou-Yong, Yang Bin^*

Department of Nephrology, Affiliated Hospital of Nantong University, Nantong 226001, China

Abstract

Klotho is highly expressed in the kidney, while soluble Klotho is detectable in the blood, urine, and cerebrospinal fluid, and has multiple hormone-like functions. The role of Klotho in kidney injury has attracted more and more attentions from researchers. Emerging evidence revealed that the transient deficiency of Klotho is an early event of acute kidney injury (AKI), whereas, in chronic kidney disease, this deficiency is sustained not only in the kidney, but also in other organ systems. Therefore, Klotho could be a potential biomarker for early diagnosis of AKI, as well as for its progression to chronic kidney disease. Moreover, Klotho might have therapeutic value to renal injury. Nevertheless, there are only few studies on the involvement of Klotho in post AKI repair. This review focused on the role of Klotho in not only kidney injury, but also its repair, in particular the relationship between Klotho and cell fate (autophagy/apoptosis/necrosis), repair/regeneration, Wnt/β-catenin and erythropoietin receptor, one of the Klotho effectors.

Key words: Klotho; acute kidney injury; repair; biomarker

Received: 2018-06-05　　Accepted: 2018-10-12

Corresponding author: 杨斌　　E-mail: by5@le.ac.uk; dryangbin@hotmail.com

DOI: 10.13294/j.aps.2018.0072

Citing This Article：

DAI Hou-Yong, Yang Bin. Research update of Klotho in kidney injury and repair. Acta Physiol Sin 2018; 70 (6): 639-643 (in Chinese with English abstract).