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Nuclear receptors and renal water transport regulation

Wang Bing, ZHANG Xiao-Yan^*

Advanced Institute for Medical Sciences, Dalian Medical University, Dalian 116044, China

Abstract

 The function of kidney is maintaining water balance of our body through regulation of urine concentration and dilution. The aquaporins are molecular basis of renal urine production and water transport, and their expression and membrane translocation are regulated delicately. Nuclear receptors are a superfamily of ligand-activated transcription factors consisting of 48 members in human. They widely participate in a variety of physiological and pathophysiological regulation including growth and development, glucose and lipid metabolism, inflammation, immunology by regulating target gene transcription and expression. Increasing evidence demonstrates that these receptors are involved in the regulation of aquaporins expression and membrane translocation in kidney, thereby playing a major role in water homeostasis. Here we review the role of nuclear receptors in regulating renal water transport. 

Key words: nuclear receptors; water transport

Received: 2018-06-05　　Accepted: 2018-10-07

Corresponding author: 张晓燕　　E-mail: zhangxy@dmu.edu.cn

DOI: 10.13294/j.aps.2018.0073

Citing This Article：

Wang Bing, ZHANG Xiao-Yan. Nuclear receptors and renal water transport regulation. Acta Physiol Sin 2018; 70 (6): 630-638 (in Chinese with English abstract).