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Role of cytochrome P450 epoxygenase-dependent arachidonic acid metabolites in kidney physiology and diseases

FANG Qin, CHEN Guang-Zhi, WANG Yan, WANG Dao-Wen^*

Division of Cardiology, Departments of Internal Medicine and Institute of Hypertension, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Hubei Key Laboratory of Genetics and Molecular Mechanisms of Cardiological Disorders (Huazhong University of Science and Technology), Wuhan 430030, China

Abstract

Kidney diseases are important causes of mortality world widely. Renal microvascular dysfunction plays a pivotal role in the development of kidney diseases. Pharmacological and biochemical tools have been used to conduct detailed studies on the metabolization of arachidonic acid by cytochrome P450 (CYP450) in renal microvasculature. CYP450 epoxygenase metabolites epoxyeicosatrienoic acids (EETs) are mainly produced in renal microvessels. EETs exhibit renoprotective effects through vasodilation, anti- hypertension, anti-apoptosis and anti-inflammation, and were reported as therapeutic targets of renal diseases. However, the ability of the kidney in generating EETs is reduced in renal diseases. Recently, the studies from transgenic animal overexpressing CYP450 epoxygenases and application of soluble epoxide hydrolase inhibitors revealed that increasing of EETs exhibits renoprotective effects in vivo. The present review focuses on the protective mechanisms of EETs in kidney physiology and diseases.

Key words: cytochrome P450 (CYP450) epoxygenase; epoxyeicosatrienoic acid (EET); kidney disease

Received: 2018-05-16　　Accepted: 2018-07-30

Corresponding author: 汪道文　　E-mail: dwwang@tjh.tjmu.edu.cn

DOI: 10.13294/j.aps.2018.0074

Citing This Article：

FANG Qin, CHEN Guang-Zhi, WANG Yan, WANG Dao-Wen. Role of cytochrome P450 epoxygenase-dependent arachidonic acid metabolites in kidney physiology and diseases. Acta Physiol Sin 2018; 70 (6): 591-599