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Research progress on pathophysiological function of SOS1 protein

HAO Pei-Qi¹, ZHANG Xin-Yu¹, GUO Hui^1,2, YANG Yang¹, AN Shu¹, LIU Ying¹, GUO Xiao-Xi¹, XU Tian-Rui¹, HAO Qian^1,*

¹Faculty of Life Science and Technology, Kunming University of Science and Technology, University Based Provincial Key Laboratory of Screening and Utilization of Targeted Drugs, Kunming 650500, China；²The First People’s Hospital of Yunnan Province, the Affiliated Hospital of Kunming University of Science and Technology, Kunming 650032, China

Abstract

Son of sevenless homolog 1 (SOS1) protein is a ubiquitously expressed adapter. As a key protein in intracellular signaling, SOS1 plays an important role in many signal transduction pathways, such as Ras and Rac signaling pathways. The abnormal expression or mutation of SOS1 is closely related to clinical diseases. In this article, we review research progress on SOS1 functions and its roles in physiology and pathophysiology.

Key words: SOS1; Ras; Rac; Noonan syndrome

Received: 2018-01-25　　Accepted: 2018-09-21

Corresponding author: 郝倩　　E-mail: haoqian26@126.com

DOI: 10.13294/j.aps.2018.0063

Citing This Article：

HAO Pei-Qi, ZHANG Xin-Yu, GUO Hui, YANG Yang, AN Shu, LIU Ying, GUO Xiao-Xi, XU Tian-Rui, HAO Qian. Research progress on pathophysiological function of SOS1 protein. Acta Physiol Sin 2018; 70 (5): 565-570 (in Chinese with English abstract).