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Research advances on preventive and therapeutic effects of hydrogen on cardiovascular and cerebrovascular diseases and underlying mechanisms

XUE Jun-Li, SONG Guo-Hua, QIN Shu-Cun^*

y Laboratory of Atherosclerosis in Colleges and Universities of Shandong Province, Institute of Atherosclerosis of Taishan Medical University, Taishan Institute for Hydrogen Biomedical Research, Taian 271000, China

Abstract

For a long time, hydrogen (H₂) has been considered as a physiological inert gas. However, recent studies have demonstrated that molecular H₂ exerts significant therapeutic effects on various disease models due to its antioxidative, anti-inflammatory and anti-apoptotic capabilities, which have also been well confirmed in many clinical trials. Cardiovascular and cerebrovascular diseases (CCVDs) are the leading cause of death in the world, constituting a serious threat to human life and public health. In this paper, we reviewed the latest research progress of the biomedical effects of H₂ in CCVDs and its possible molecular mechanisms, in the hope of providing new clues for the treatment of some CCVDs.

Key words: hydrogen; cardiovascular and cerebrovascular diseases; biomedical effects; molecular mechanism

Received: 2018-01-19　　Accepted: 2018-09-13

Corresponding author: 秦树存　　E-mail: shucunqin@hotmail.com

DOI: 10.13294/j.aps.2018.0060

Citing This Article：

XUE Jun-Li, SONG Guo-Hua, QIN Shu-Cun. Research advances on preventive and therapeutic effects of hydrogen on cardiovascular and cerebrovascular diseases and underlying mechanisms. Acta Physiol Sin 2018; 70 (5): 557-564 (in Chinese with English abstract).