Voltage-gated sodium channels regulate the biological functions of macrophages
ZHOU Rong, GOU Meng, XIAO Rong*
School of Life Sciences, Liaoning Normal University, Dalian 116081, China
Abstract
Voltage-gated sodium channels (VGSCs) play very important roles in the generation and conduction of action potential in the excitable cells. Recent studies have showed that VGSCs are also expressed in the macrophages and regulate a variety of biological functions, including phagocytosis, endosomal acidification, podosome formation, polarization, and antiviral responses, etc. This paper will review the roles of VGSCs in regulating the biological functions of macrophages and the underlying mechanisms, which would provide clues for the studies of the functions of VGSCs in the other immune cells.
Key words: Macrophages; voltage-gated sodium channels; phagocytosis; polarization; endosomal acidification; podosome; antiviral responses
Received: 2017-11-22 Accepted: 2018-07-05
Corresponding author: 肖蓉 E-mail: xiaorong_lnnu@126.com
DOI: 10.13294/j.aps.2018.0048
Citing This Article:
ZHOU Rong, GOU Meng, XIAO Rong. Voltage-gated sodium channels regulate the biological functions of macrophages. Acta Physiol Sin 2018; 70 (4): 455-461 (in Chinese with English abstract).