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Role of skeletal muscle fat ectopic deposition in insulin resistance induced by high-fat diet

LI Ting, RUAN Ding-Guo, GAO Jin-Jin, WANG Huan, XU Xiao-Yang^*

School of Physical Education and Sports Science, South China Normal University, Guangzhou 511400, China

Abstract

Consumption of high-fat diet leads to the increase of fat intake and consequent excess storage of fat in the body. When the regular adipose tissues reach their capacity to store fat, ectopic fat is stored around and within non-adipose tissues, such as the liver and skeletal muscle, which plays important roles in glucose metabolism. Hence ectopic fat accumulation in major insulin target tissues is a critical determinant of insulin resistance (IR) and various related metabolic syndromes. Recent studies have shown that skeletal muscle lipid accumulation is more closely related with IR than general obesity and accounts for approximately 80%–90% type 2 diabetes, since the skeletal muscle is the largest glucose disposal site. Therefore, the association between skeletal muscle lipid and IR has attracted more and more research interest. This review summarized the role of ectopic skeletal muscle lipid in IR induced by high-fat diet and its possible mechanisms.

Key words: Skeletal muscle; ectopic fat; insulin resistance; adipokine; lipid intermediates

Received: 2018-01-02　　Accepted: 2018-07-11

Corresponding author: 徐晓阳　　E-mail: 873479312@qq.com

DOI: 10.13294/j.aps.2018.0050

Citing This Article：

LI Ting, RUAN Ding-Guo, GAO Jin-Jin, WANG Huan, XU Xiao-Yang. Role of skeletal muscle fat ectopic deposition in insulin resistance induced by high-fat diet. Acta Physiol Sin 2018; 70 (4): 433-444 (in Chinese with English abstract).