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Research progress of mitochondrial fission and fusion related proteins

ZHAO Li, ZHOU Qiao-Xia, WANG Shuan, YAN He, WANG Xue-Er, FAN Fei, HUANG Fei-Jun^*

Department of Forensic Pathology, West China School of Basic Science and Forensic Medicine, Sichuan University, Chengdu 610041, China

Abstract

Mitochondria are an essential component of multicellular life and play important roles in the health of the cells and the body. Mitochondria can produce energy by oxidative phosphorylation, mediate calcium and reactive oxygen signal transduction, and regulate cell apoptosis. Recent studies indicate that mitochondria continually change their shapes and distribution by fission and
fusion, which are collectively termed mitochondrial dynamics. Mitochondrial dynamics play critical roles in maintaining mitochondrial function. This review focuses on the structure and biological functions of mitochondrial fission and fusion related proteins in mammal cells.

Key words: mitochondrial dynamics; mitochondrial fission; mitochondrial fusion; dynamin-related protein 1; optic atrophy 1; mitofusin-1/2

Received: 2018-01-04　　Accepted: 2018-07-13

Corresponding author: 黄飞骏　　E-mail: fjhuang60123@163.com

DOI: 10.13294/j.aps.2018.0054

Citing This Article：

ZHAO Li, ZHOU Qiao-Xia, WANG Shuan, YAN He, WANG Xue-Er, FAN Fei, HUANG Fei-Jun. Research progress of mitochondrial fission and fusion related proteins. Acta Physiol Sin 2018; 70 (4): 424-432 (in Chinese with English abstract).