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Research progress of the relationship between liver X receptor and inflammatory- related diseases

GAO Bi-Cong¹, CHEN Quan², SUN Ting¹, WANG De-Ming¹, XIAO Ji^1,*

¹Department of Anesthesiology, The Second Hospital Affiliated to University of South China, Hengyang 421001, China；²Department of Anesthesiology, The Eighth Hospital of Changsha, Changsha 410100, China

Abstract

The liver X receptors (LXRs) are members of the nuclear receptor superfamily. The activated LXRs have a variety of biological functions, for instance they can not only regulate the metabolism of cholesterol, fatty acids and glucose, but also play an important role in immune inflammatory response. Massive studies have shown that LXRs are involved in the occurrence and progress of inflammatory-related diseases, and can inhibit the inflammation of some inflammatory-related diseases in the nervous system, the respiratory system, and the cardiovascular system. In this review, we summarized the recent progress regarding LXRs in inflammatory-related diseases, including the structure, function and anti-inflammatory mechanism of LXRs, in order to provide new methods for preventing and treating inflammatory-related diseases.

Key words: liver X receptors; inflammatory-related diseases; anti-inflammatory mechanism

Received: 2017-09-03　　Accepted: 2017-12-05

Corresponding author: 肖继　　E-mail: 253477652@qq.com

DOI: 10.13294/j.aps.2018.0012

Citing This Article：

GAO Bi-Cong, CHEN Quan, SUN Ting, WANG De-Ming, XIAO Ji. Research progress of the relationship between liver X receptor and inflammatory- related diseases. Acta Physiol Sin 2018; 70 (3): 335-341 (in Chinese with English abstract).