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Molecular mechanisms of anti-inflammatory action of AMPK

LIU Ming-Yue¹, ZHANG Ming-Jia¹, XIE Ming-Jie^1,2,*

¹College of Life Sciences, Liaoning Normal University, Dalian 116081, China；²Key Laboratory of Biotechnology and Drug Discovery of Liaoning Province, Dalian 116081, China

Abstract

 AMP-activated protein kinase (AMPK), an evolutionarily conserved serine/threonine protein kinase, is known as the “cellular energy regulator” and a key molecule to maintain the energy balance of cells and organism. Recent studies have shown that AMPK exerts anti-inflammatory effects mainly through activating SIRT1, PGC-1α, p53, FoxO3a and p300, and down-regulating the activity of various inflammatory related proteins such as NF-κB and AP-1. This article reviews the molecular mechanisms of the anti- inflammatory effects of AMPK, and provides some clues for the development of AMPK-targeted therapeutics to treat inflammation and related diseases.

Key words: AMP-activated protein kinase; anti-inflammatory mechanism; NF-κB; AP-1

Received: 2017-11-15　　Accepted: 2018-01-05

Corresponding author: 谢明杰　　E-mail: xmj1222@sina.com

DOI: 10.13294/j.aps.2018.0020

Citing This Article：

LIU Ming-Yue, ZHANG Ming-Jia, XIE Ming-Jie. Molecular mechanisms of anti-inflammatory action of AMPK. Acta Physiol Sin 2018; 70 (3): 329-334 (in Chinese with English abstract).