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Research advances in the regulation of cardiovascular metabolic disorders and its related risk factors by C1q/TNF related proteins

ZHANG Shi-Han¹, DU Yun-Hui², YU Hai-Cun¹, LI Yu-Ming^3,*, LIU Hui-Rong¹

¹Department of Physiology and Pathophysiology, School of Basic Medical Sciences, Capital Medical University, Beijing 100069, China；²Beijing Institute of Heart, Lung and Blood Vessel Diseases, Beijing Anzhen Hospital, Capital Medical University, Beijing 100029, China；³Department of Basic Medical Sciences, Yanjing Medical College, Capital Medical University, Beijing 101300, China

Abstract

The complement C1q/TNF related protein (CTRP) family is rapidly growing and currently comprises 15 members. Although CTRP proteins share a common structure composed of four distinct domains: a signal peptide at the N terminus, a short variable region, a collagenous domain, and a C-terminal globular domain, which is homologous to adiponectin, each CTRP has a unique tissue expression profile and varied function. In this review we focus on the biochemistry and pleiotropic functions of CTRPs as new molecular mediators regulating cardiovascular metabolic disorders and its related risk factors diseases.

Key words: complement C1q/TNF related protein; expression; function; disease

Received: 2017-09-12　　Accepted: 2017-11-02

Corresponding author: 李玉明　　E-mail: ymlea@sina.com

DOI: 10.13294/j.aps.2018.0014

Citing This Article：

ZHANG Shi-Han, DU Yun-Hui, YU Hai-Cun, LI Yu-Ming, LIU Hui-Rong. Research advances in the regulation of cardiovascular metabolic disorders and its related risk factors by C1q/TNF related proteins. Acta Physiol Sin 2018; 70 (3): 310-318 (in Chinese with English abstract).