Issue Archive

Research progress of histone deacetylase 6 inhibitors in the therapy of ischemic stroke

ZHANG Chen-Chen, LU Fang, LIANG Jia-Qiang, ZHOU Yan-Fang^*

Department of Pathophysiology, Guangdong Medical University, Dongguan 523808, China

Abstract

The protein acetylation by histone acetyltransferases (HATs) and histone deacetylases (HDACs) plays a significant role in the development and maturation of the nervous system. HDAC6, belonging to class II HDACs, by regulating the survival, differentiation and maturation of neural cells, plays an important role in the development of the nervous system and participates in multiple pathological processes of cerebral ischemic injury. In addition, HDAC6 participates in the regulation of cognition and emotion of the brain. This article summarized the latest research results in recent years and expounded that HDAC6 inhibitors could produce a positive and effective neuroprotective effect on ischemic stroke by reducing the neuronal damage induced by excitotoxicity and oxidative stress, depressing the release of inflammatory mediators, inhibiting the apoptosis of neurons and promoting the growth of nerve and blood vessel.

Key words: histone deacetylase 6; inhibitor; ischemic stroke

Received: 2017-11-10　　Accepted: 2018-02-06

Corresponding author: 周艳芳　　E-mail: fangfang772003@163.com

DOI: 10.13294/j.aps.2018.0023

Citing This Article：

ZHANG Chen-Chen, LU Fang, LIANG Jia-Qiang, ZHOU Yan-Fang. Research progress of histone deacetylase 6 inhibitors in the therapy of ischemic stroke. Acta Physiol Sin 2018; 70 (3): 301-309 (in Chinese with English abstract).