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The role of adventitia in hypoxic vascular remodeling

YU Fu-Yang, YANG Sheng-Chang, JI En-Sheng^*

Department of Physiology, College of Basic Medicine, Hebei University of Chinese Medicine, Shijiazhuang 050091, China

Abstract

As an important site for the production, storage and release of key regulators for vascular function, the vascular adventitia is thought to be a damage sensing tissue in the vascular wall under certain conditions. The adventitial cells are usually the first ones to respond to vascular stress or injury, and consequently affect the structure and function of blood vessel wall. Growing lines of evidence have shown that the vascular adventitia exhibits the earliest and most prominent changes in vascular remodeling due to hypoxia and related pulmonary hypertension and atherosclerosis. In particular, fibroblasts play an important role in the adaptation and regulation to local microenvironmental changes. This review focuses on the role of vascular adventitia in hypoxia-induced vascular remodeling and the underlying molecular mechanisms.

Key words: adventitia; hypoxia; fibroblast; vasa vasorum; hypoxia inducible factor-1α

Received: 2017-08-30　　Accepted: 2018-03-21

Corresponding author: 吉恩生　　E-mail: jesphy@126.com

DOI: 10.13294/j.aps.2018.0025

Citing This Article：

YU Fu-Yang, YANG Sheng-Chang, JI En-Sheng. The role of adventitia in hypoxic vascular remodeling. Acta Physiol Sin 2018; 70 (2): 211-216 (in Chinese with English abstract).