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Effect of different concentrations of calcitonin gene-related peptide on the long-term potentiation in hippocampus of mice

WU Xin, ZHENG Wan-Jun, LV Ming-Hui, SU Shao-Hua, ZHANG Song-Jiang, GAO Jian-Feng^*

Department of Physiology, School of Basic Medicine, Henan University of Traditional Chinese Medicine, Zhengzhou 450008, China

Abstract

The purpose of this study was to explore the effects of different concentrations of calcitonin gene-related peptide (CGRP) on long-term potentiation (LTP) in the hippocampus of mice. C57BL/6J mice (30 days old) were randomly divided into control group, three CGRP groups, and CGRP + CGRP8-37 group (10 mice for each group). Different concentrations of CGRP (50, 100 and 200 nmol/L) were given to the hippocampal slices of mice. The presynaptic release of neurotransmitters and the induction of LTP were measured by extracellular field recording techniques. The result showed that different concentrations of CGRP did not affect the presynaptic release of neurotransmitters, but 100 and 200 nmol/L CGRP increased the amplitude of LTP induced in the hippocampus of mice. This facilitation effect of CGRP was blocked by its specific antagonist CGRP8-37. These results suggest that CGRP dose-dependently facilitates the induction of LTP in the hippocampus of mice through its specific receptor.

Key words: Calcitonin gene-related peptide; hippocampus; synaptic plasticity; learning and memory

Received: 2017-04-26　　Accepted: 2018-01-11

Corresponding author: 高剑峰　　E-mail: jc.gjfeng@hotmail.com

DOI: 10.13294/j.aps.2018.0001

Citing This Article：

WU Xin, ZHENG Wan-Jun, LV Ming-Hui, SU Shao-Hua, ZHANG Song-Jiang, GAO Jian-Feng. Effect of different concentrations of calcitonin gene-related peptide on the long-term potentiation in hippocampus of mice. Acta Physiol Sin 2018; 70 (1): 17-22 (in Chinese with English abstract).