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The mechanism and function of hippocampal neural oscillation

LU Ning¹, XING Dan-Qin^2,3, SHENG Tao³, LU Wei^3,*

¹Chien-Shiung Wu College, Southeast University, Nanjing 210096, China；²College of Geographic and Biologic Information, Nanjing University of Posts and Telecommunications, Nanjing 210046, China；³The Key Laboratory of Developmental Genes and Human Disease, Ministry of Education, Institute of Life Sciences, Southeast University, Nanjing 210096, China

Abstract

Neural oscillation is rhythmic or repetitive neural activity in the central nervous system that is usually generated by oscillatory activity of neuronal ensembles, reflecting regular and synchronized activities within these cell populations. According to several oscillatory bands covering frequencies from approximately 0.5 Hz to >100 Hz, neural oscillations are usually classified as delta oscillation (0.5–3 Hz), theta oscillation (4–12 Hz), beta oscillation (12–30 Hz), gamma oscillation (30–100 Hz) and sharp-wave ripples (>100 Hz ripples superimposed on 0.01–3 Hz sharp waves). Neural oscillation in different frequencies can be detected in different brain regions of human and animal during perception, motion and sleep, and plays an essential role in cognition, learning and memory process. In this review, we summarize recent findings on neural oscillations in hippocampus, as well as the mechanism and function of hippocampal theta oscillation, gamma oscillation and sharp-wave ripples. This review may yield new insights into the functions of neural oscillation in general.

Key words: hippocampus, neural oscillation; theta oscillation ; gamma oscillation ; sharp-wave ripples

Received: 2017-04-20　　Accepted: 2017-08-18

Corresponding author: 陆巍　　E-mail: luwei@seu.edu.cn

DOI: 10.13294/j.aps.2017.0052

Citing This Article：

LU Ning, XING Dan-Qin, SHENG Tao, LU Wei. The mechanism and function of hippocampal neural oscillation. Acta Physiol Sin 2017; 69 (5): 647-656 (in Chinese with English abstract).