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Recent progress of mitochondrial quality control in ischemic heart disease and its role in cardio-protection of vagal nerve

XUE Run-Qing, XU Ma, YU Xiao-Jiang , LIU Long-Zhu, ZANG Wei-Jin^*

Department of Pharmacology, Xi’an Jiaotong University Health Science Center, Xi’an 710061, China

Abstract

Ischemic heart disease (IHD) is the life-threatening cardiovascular disease. Mitochondria have emerged as key participants and regulators of cellular energy demands and signal transduction. Mitochondrial quality is controlled by a number of coordinated mechanisms including mitochondrial fission, fusion and mitophagy, which plays an important role in maintaining healthy mitochondria and cardiac function. Recently, dysfunction of each process in mitochondrial quality control has been observed in the ischemic hearts. This review describes the mechanism of mitochondrial dynamics and mitophagy as well as its performance linked to myocardial ischemia. Moreover, in combination with our study, we will discuss the effect of vagal nerve on mitochondria in cardio-protection.

Key words: mitochondrial quality control; mitochondrial dynamics ; mitophagy ; ischemic heart disease ; vagal nerve

Received: 2017-04-24　　Accepted: 2017-08-25

Corresponding author: 臧伟进　　E-mail: zwj@xjtu.edu.cn

DOI: 10.13294/j.aps.2017.0056

Citing This Article：

XUE Run-Qing, XU Ma, YU Xiao-Jiang , LIU Long-Zhu, ZANG Wei-Jin. Recent progress of mitochondrial quality control in ischemic heart disease and its role in cardio-protection of vagal nerve. Acta Physiol Sin 2017; 69 (5): 579-586 (in Chinese with English abstract).