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Regulation of vascular function by nitric oxide-related S-nitrosylation

Li Jing, Feng Juan, Wang Xian^*

Department of Physiology and Pathophysiology, School of Basic Medical Sciences, Peking University Health Science Center, Key laboratory of Molecular Cardiovascular Science, Ministry of Education, Beijing 100191, China

Abstract

Nitric oxide (NO), well known as the endothelium-derived relaxing factor (EDRF), has become increasingly recognized as an important determinant of cardiovascular diseases. A molecular pathway by which NO accomplishes various biochemical processes is the cGMP-independent post-translational modification of protein, S-nitrosylation. Here we review the biochemistry and regulating mechanisms of NO-related S-nitrosylation of proteins, and discuss the multiple roles of S-nitrosylation in vascular functions and pathology in particular.

Key words: Nitric oxide; S-nitrosylation ; denitrosylation ; cardiovascular disease

Received: 2017-04-25　　Accepted: 2017-07-28

Corresponding author: 王宪　　E-mail: xwang@bjmu.edu.cn

DOI: 10.13294/j.aps.2017.0069

Citing This Article：

Li Jing, Feng Juan, Wang Xian. Regulation of vascular function by nitric oxide-related S-nitrosylation. Acta Physiol Sin 2017; 69 (5): 557-570 (in Chinese with English abstract).