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Potassium channels and autophagy

YANG Shuo, LIU Jia, QU Chao, SUN Jia, ZHANG Bing-Qiang, SUN Ya-Ru, ZOU Wei

College of Life Sciences, Liaoning Normal University, Dalian 116081, China； Key Laboratory of Cell Transplantation, Ministry of Health, Qingdao 266000, China； Department of Biological Science and Technology, Dalian University of Technology, Dalian 116024, China

Abstract

Potassium channels have multitudinous subtypes, which are widely distributed on cell membranes. They affect various cellular physiological functions through participating in processes such as resting potential formation, substance transportation, enzyme activity and cellular communication. Autophagy is a significant mechanism to maintain intracellular metabolic homeostasis. The abnormity of autophagy may lead to the occurrence and development of multiple diseases. Recently, it has been reported that K+ channels and cell autophagy are closely related. Here, we reviewed the recent research progresses on regulation of autophagy signaling, autophagy flux or autophagolysosome formation by K+ channel, and discussed the physiological significance of autophagy regulation by K + channel.

Key words: Ion channel; potassium channel ; autophagy

Received: 2016-11-14　　Accepted: 2017-04-10

Corresponding author: 邹伟　　E-mail: weizou60@126.com

Citing This Article：

YANG Shuo, LIU Jia, QU Chao, SUN Jia, ZHANG Bing-Qiang, SUN Ya-Ru, ZOU Wei. Potassium channels and autophagy. Acta Physiol Sin 2017; 69 (4): 509-514 (in Chinese with English abstract).