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[Hippocampal cAMP response element binding protein and antidepressant treatments.] [Ariticle in Chinese]

Chen Lin, ZHAO Yu-Nan, DAI Jian-Guo, WANG Zhong-Li, HUANG Yu-Fang^*

Department of Preclinical Medicine Combined with Traditional Medicine and Western Medicine, Preclinical Medical School, Nanjing University of Traditional Medicine, Nanjing 210046, China

Abstract

With the deepening research on pathogenesis of depression, the focus has diverted from the mechanism of regulatingmonoamines to the basic pathophysiology of depression and the long-term mechanism of antidepressant treatments. cAMP responseelement binding protein (CREB) in the brain, especially in the hippocampi, as a converging agent of many intracellular signalingtransduction pathways is getting increasing attention. To better understand the basic pathophysiology of depression and the long-termmechanism of antidepressant treatments, it is significant to make clear the correlation between hippocampal CREB and antidepressanttreatments. This review mainly refers to the formation of CREB and its distribution in hippocampi, the upstream signaling transductionpathways of hippocampal CREB and antidepressant treatments, and the possible antidepressant mechanisms by regulating hippocampalCREB.

Key words: cAMP response element binding protein; hippocampus; antidepressants

Received: 2010-09-03　　Accepted: 2010-10-11

Corresponding author: 黄玉芳　　E-mail: yufanghnj@163.com

Citing This Article：

Chen Lin, ZHAO Yu-Nan, DAI Jian-Guo, WANG Zhong-Li, HUANG Yu-Fang. [Hippocampal cAMP response element binding protein and antidepressant treatments.] [Ariticle in Chinese] . Acta Physiol Sin 2010; 62 (6): 489-494 (in Chinese with English abstract).