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[Relation between fat mass, fat free mass and ventilatory function in children and adolescents.] [Ariticle in Chinese]

WANG Dan-Yang, FENG Kui, CHEN Li, ZU Shu-Yu, HAN Shao-Mei, ZHU Guang-Jin

Department of Physiology and Pathophysiology； Department of Epidemiology and Statistics, Institute of Basic Medical Sciences, Chinese Academy of Medical Sciences, Peking Union Medical College, Beijing 100005, China

Abstract

The aim of the present study was to evaluate the relation between fat mass (FM), fat free mass (FFM) and ventilatoryfunction in children and adolescents. 1 174 healthy children and adolescents (583 males and 591 females) aged 10-18 years were selectedfrom Heilongjiang Province through random sampling by means of questionnaire and physical examination, and measured for height,weight, waist to hip ratio (WHR), FM, FFM and ventilatory function. The data were analyzed by means of independent-samples t test,Pearson correlation analysis and multi-factors regression analysis. Regardless of sex, an independent positive correlation was found(P<0.001) between age and FFM index (FFMI). FM index (FMI) correlated negatively with age in males (P<0.001), but positively with age in females (P<0.001). Regardless of sex, FFMI correlated positively with forced vital capacity (FVC), forced expiratoryvolume in one second (FEV1), peak expiratory flow (PEF), forced expiratory flow at 25% of forced vital capacity (FEF25%), FEF50%,and maximal mid-expiratory flow (MMEF) (P<0.05), while negatively with FEV1/FVC (P<0.01). FFMI was correlated positivelywith FEF75% in males (P<0.05), but not correlated in females. In males, FMI correlated negatively with FEV1, FEV1/FVC, PEF,FEF25%, FEF50%, FEF75% and MMEF (P<0.05), but not correlated with FVC. No correlation was found between the ventilatoryfunction indices and FMI in females. Except FEV1/FVC and FEF75% in males, the effect of FFMI in predicting ventilatory functionwas higher than FMI regardless of sex. Moreover, the predicting effect of FFMI was higher in males than that in females. Growth spurtof lung function occurred in the ages of 12-15 years in males, while in the ages of 12, 13 and 18 years in females. During the period ofgrowth spurt of lung function, regardless of sex, the effect of FFMI in predicting the lung function was higher than that of age. Inconclusion, regardless of sex, FFMI correlates positively with ventilatory function, as a reflection of muscle mass. The effect of FFMin predicting ventilatory function is higher in males than that in females. FM correlates negatively with ventilatory function in males,but not in females. The rapid growth of height and FFM are possibly the main reasons for growth spurt of lung function.

Key words: child; adolescent; body composition; forced expiratory flow rates; forced vital capacity; growth spurt

Received: 2010-06-07　　Accepted: 2010-08-13

Corresponding author: 冯逵　　E-mail: fengkui@sina.com

Citing This Article：

WANG Dan-Yang, FENG Kui, CHEN Li, ZU Shu-Yu, HAN Shao-Mei, ZHU Guang-Jin. [Relation between fat mass, fat free mass and ventilatory function in children and adolescents.] [Ariticle in Chinese] . Acta Physiol Sin 2010; 62 (5): 455-464 (in Chinese with English abstract).