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[Function and biological activities of the autotaxin-LPA axis.] [Article in Chinese]

LI Zong-Wei, ZHAO Ya-Rui, ZHAO Chao, FU Rong, LI Zhuo-Yu*

Institute of Biotechnology, Key Laboratory of Chemical Biology and Molecular Engineering of National Ministry of Education, Shanxi University, Taiyuan 030006, China

Abstract

Autotaxin (ATX), a member of nucleotide pyrophosphatase/phosphodiesterase (NPP) family, is also named as phosphodiesterase Iα (PD-Iα) or NPP2. ATX is the unique member among the NPPs that can function as a lysophospholipase D (lysoPLD), converting lysophosphatidylcholine into lysophosphatidic acid (LPA). LPA acts on specific G-protein-coupled receptors to elicit a wide range of cellular response, including cell proliferation, cell migration and cell contraction, etc. As the major LPA-producing phospholipase, many ATX’s features and functions are dependent on the production of LPA. ATX and LPA together form the ATX-LPA functional axis. The present review summarizes the current progress in function and biological activities of ATX-LPA axis.

Key words: autotoxin; lysophospholipase D; lysophosphatidic acid

Received: 2011-04-28　　Accepted: 2011-06-29

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Citing This Article：

LI Zong-Wei, ZHAO Ya-Rui, ZHAO Chao, FU Rong, LI Zhuo-Yu*. [Function and biological activities of the autotaxin-LPA axis.] [Article in Chinese]. Acta Physiol Sin 2011; 63 (6): 601-610 (in Chinese with English abstract).