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A study on the location of immuno-suppressive factor(s) in restraint rats and mice

WANG Jing-Xue, CHEN Wei, Mei Lin, LAI Ling, TANG Hong-Yu, FAN Shao-Guang

Department of Physiology, Beijing Medical University, Beijeng 100083，China

Abstract

A serum lymphocyte-proliferation suppressive factor(s)in duced by restraintstress over 10 h was found in previous studies in both rats and mice. The presentstudy was undertaken to investigate the sites of its production. The results showthat large doses of irradiation and cyclophosphamide (CY) decreased the totalnumber of splenic nucleated cells, but the production of the suppressive factor wasinhibited only by irradiation. This indicates that the drop in total number oflymphocytes does not play any key role in the production of the serum suppressivefactor. Cell classification showed that the ratio of T to B cell was decreased byradiation but increased by CY, suggesting that this ratio may be relevant to theproduction of the factor. Inhibition of the production was also observed in nudemouse (an animal showing a lack of T cell activity), again supporting that T cellsare involved in the production of the inhibitory factor.

Key words: Stress; lymphocyte proliferation; immuno-suppressive factor; T cells; B cells

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Citing This Article：

WANG Jing-Xue, CHEN Wei, Mei Lin, LAI Ling, TANG Hong-Yu, FAN Shao-Guang. A study on the location of immuno-suppressive factor(s) in restraint rats and mice. Acta Physiol Sin 1992; 44 (6): 541-548 (in Chinese with English abstract).