Issue Archive

[Progress in mechanisms underlying melamine toxicity in central nervous system.] [Article in Chinese]

YANG Jia-Jia, AN Lei, YANG Zhuo, ZHANG Tao^*

College of Life Science； College of Medicine, Nankai University, Tianjin 300071, China

Abstract

In recent years there have been more widely and deeply studies in investigating melamine toxicity. Generally, it is believed that the main target of melamine is the urinary system. However, previous studies revealed that it also had additional biological actions. Obviously, the toxicity mechanisms of melamine have not been fully clarified. It is well known that fetus and infant periods play the most fundamental role in the brain development. And melamine can pass through the placental and blood-brain barrier, and then exerts toxic effects on the central nervous system. This article reviewed the reports about the topic in recent years, for better understanding the dangers of melamine to infants and providing experimental data for further study.

Key words: melamine; central nervous system; ion channels; learning and memory; synaptic transmission and plasticity

Received: 2011-10-19　　Accepted: 2011-12-12

Corresponding author: 张涛　　E-mail: zhangtao@nankai.edu.cn

Citing This Article：

YANG Jia-Jia, AN Lei, YANG Zhuo, ZHANG Tao. [Progress in mechanisms underlying melamine toxicity in central nervous system.] [Article in Chinese]. Acta Physiol Sin 2012; 64 (2): 238-244 (in Chinese with English abstract).