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[Mitochondria couple cellular Ca(2+) signal transduction.] [Article in Chinese]

SONG Ya-Man, LU Zhong-Qiu, GUAN Min-Xin^*

Attardi Institute of Mitochondrial Biomedicine, Wenzhou Medical College, Wenzhou 325035, China； College of Life Sciences, Zhejiang University, Hangzhou 310058, China

Abstract

It has been shown that mitochondria not only control their own Ca2+ concentration ([Ca2+]), but also exert an influence over Ca2+ signaling of the entire cell, including the endoplasmic reticulum or the sarcoplasmic reticulum, the plasma membrane, and the nucleus. That is to say, mitochondria couple cellular metabolic state with Ca2+ transport processes. This review focuses on the ways in which the mitochondrial Ca2+ handling system provides integrity and modulation for the cell to cope with the complex actions throughout its life cycle, enumerates some indeterminate aspects about it, and finally, prospects directions of future research.

Key words: Mitochondria; Ca2+; signal transduction; myocardium; physiology

Received: 2011-09-21　　Accepted: 2012-02-22

Corresponding author: 管敏鑫　　E-mail: gminxin88@gmail.com

Citing This Article：

SONG Ya-Man, LU Zhong-Qiu, GUAN Min-Xin. [Mitochondria couple cellular Ca(2+) signal transduction.] [Article in Chinese]. Acta Physiol Sin 2012; 64 (3): 333-340 (in Chinese with English abstract).