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[Protective effects of sodium nitrite preconditioning against alcohol-induced acute liver injury in mice.] [Article in Chinese]

HE Xi, BI Xue-Yuan, WANG Hao, YU Xiao-Jiang, ZANG Wei-Jin^*

Department of Pharmacology, School of Medicine, Xi’an Jiaotong University, Xi’an 710061, China

Abstract

Ischemia-reperfusion injury (IRI) has been recognized as a serious problem for therapy of cardiovascular diseases. Calcium regulation appears to be an important issue in the study of IRI. This article reviews calcium regulation in myocardial and vascular IRI, including the calcium overload and calcium sensitivity in IRI. This review is focused on the key players in Ca2+ handling in IRI, including membrane damage resulting in increase in Ca2+ influx, reverse-mode of Na+-Ca2+ exchangers leading to increased Ca2+ entry, the decreased activity of sarcoplasmic reticulum (SR) Ca2+-ATPase causing SR Ca2+ uptake dysfunction, and increased activity of Rho kinase. These key players in Ca2+ homeostasis will provide promising strategies and potential targets for therapy of cardiovascular IRI.

Key words: ischemia-reperfusion injury; calcium overload; calcium sensitivity; cardiovascular system

Received: 2011-11-30　　Accepted: 2011-12-29

Corresponding author: 臧伟进　　E-mail: zwj@mail.xjtu.edu.cn

Citing This Article：

HE Xi, BI Xue-Yuan, WANG Hao, YU Xiao-Jiang, ZANG Wei-Jin. [Protective effects of sodium nitrite preconditioning against alcohol-induced acute liver injury in mice.] [Article in Chinese]. Acta Physiol Sin 2012; 64 (3): 321-326 (in Chinese with English abstract).