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[P21-activated kinases and their role in the nervous system] [Articlein Chinese]

QIN Yuan, DING Yue-Min, XIA Qiang

Department of Physiology, Zhejiang University School of Medicine, Hangzhou 310058, China； Medical School, Zhejiang University City College, Hangzhou 310015, China.

Abstract

P21-activated kinases (PAK) participate in a variety of important cellular activities, such as cytoskeleton remodeling, cell migration, cell cycle regulation, and apoptosis or survival. PAK also has an important impact on brain development, neuronal differentiation, and regulation of synaptic plasticity in the nervous system. PAK abnormalities result in diseases including cancer, Parkinson’s disease (PD), Alzheimer’s disease (AD) and neural retardation. Therefore, it is of vital physiological significance to investigate the neuronal function of PAK. In this paper we review the advancement of research on the neuronal biological function and the underlying mechanisms of PAK.

Key words: P21-activated kinases; nervous system; diseases

Received: 2012-04-13　　Accepted: 2012-08-01

Corresponding author: 丁悦敏　　E-mail: dingyuemin@zucc.edu.cn

Citing This Article：

QIN Yuan, DING Yue-Min, XIA Qiang. [P21-activated kinases and their role in the nervous system] [Articlein Chinese]. Acta Physiol Sin 2012; 64 (6): 700-706 (in Chinese with English abstract).