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[Interleukin-1β inhibits the amplitudes of voltage-gated Na(+) currents and action potential in cultured cortical neurons of rat.] [Article in Chinese]

QI Cui, ZHANG Wei-Wei, LI Xiao-Nan, ZHOU Chen^*

The College of Life Sciences, Hebei University, Baoding 071002, China； School of Basic Medical Science, Hebei University, Baoding 071000, China

Abstract

Interleukin-1β (IL-1β) is an important proinflammatory cytokine and plays key roles in physiological and pathophysiological processes of central nervous system (CNS). The voltage-gated Na+ channels are essential for electrical properties of excitable cells and control the excitability and action potential (AP) of neurons. Recent studies have showed the relationship between IL-1β and voltage-gated channels. In this work, cultured cortical neurons of rat were treated by 10 ng/mL of IL-1β for 24 h, and then voltage-gated Na+ currents were recorded using voltage-clamp technique. The results indicated that IL-1β reduced the amplitude of Na+ currents without any changes in activation or inactivation properties. The current-clamp recording showed that IL-1β reduced the amplitude of AP but not the threshold. These data indicate that IL-1β inhibits the voltage-gated Na+ currents and the amplitude of AP, and suggest that essential roles of voltage-gated Na+ channels may be changed by IL-1β. New information about effects of IL-1β on injuries and diseases of CNS was provided.

Key words: interleukin-1β; cortical neurons; voltage-gated Na+ currents; action potential

Received: 2010-11-25　　Accepted: 2011-01-21

Corresponding author: 周辰　　E-mail: zezhou@sina.com

Citing This Article：

QI Cui, ZHANG Wei-Wei, LI Xiao-Nan, ZHOU Chen. [Interleukin-1β inhibits the amplitudes of voltage-gated Na(+) currents and action potential in cultured cortical neurons of rat.] [Article in Chinese]. Acta Physiol Sin 2011; 63 (2): 131-137 (in Chinese with English abstract).