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[The expression of a novel estrogen receptor, GPR30, in epithelial ovarian carcinoma and its correlation with MMP-9.] [Ariticle in Chinese]

LIU Hui-Di, YAN Yan, CAO Xue-Feng, TAN Pei-Zhu, WEN Hai-Xia, LV Chun-Mei, LI Xiao-Mei, LIU Guo-Yi

Department of Physiology, Harbin Medical University, Harbin 150081, China； Department of Pathology, the Third Affiliated Hospital of Harbin Medical University, Harbin 150040, China

Abstract

The aim of the present study is to investigate the expression of a novel estrogen receptor, G protein-coupled receptor 30 (GPR30) and its correlation with matrix metalloproteinases-9 (MMP-9) in epithelial ovarian cancer (EOC). Ovary tissues were obtained from 39 female patients, including 30 cases of EOC and 9 cases of benign ovarian tumor. Four normal ovary tissues were used as control. Immunohistochemical staining was used to detect the expressions of GPR30 and MMP-9. Chi square test, Fisher’s exact test and Spearman’s rank correlation analysis were used for statistical analysis. The results showed that GPR30 overexpression rate in EOC cases was significantly higher than those in benign ovarian tumor and normal ovary cases. Whereas MMP-9 overexpression rate in EOC cases was significantly higher than that in normal ovary cases, without any difference to that in benign ovarian tumor cases. To demonstrate the relationship between GPR30 and clinicopathological variables of EOC, we further analyzed the pathology type, FIGO stage and age of patients sampled in our study. The analysis showed there were significant differences of GPR30 overexpression rate among various pathology types and different FIGO stages (P<0.05), and no significant difference of both GPR30 and MMP-9 among three age groups (P>0.05). Moreover, GPR30 expression was positively correlated with MMP-9 (rs=1.000, P=0.002). These results suggest that GPR30 may be involved in the invasion and metastasis of EOC, being a potential index of EOC early diagnosis and malignancy grade prediction.

Key words: epithelial ovarian carcinoma; G protein-coupled receptor 30; matrix metalloproteinases-9

Received: 2010-06-02　　Accepted: 2010-07-02

Corresponding author: 刘国艺　　E-mail: liuguoyi@126.com

Citing This Article：

LIU Hui-Di, YAN Yan, CAO Xue-Feng, TAN Pei-Zhu, WEN Hai-Xia, LV Chun-Mei, LI Xiao-Mei, LIU Guo-Yi. [The expression of a novel estrogen receptor, GPR30, in epithelial ovarian carcinoma and its correlation with MMP-9.] [Ariticle in Chinese] . Acta Physiol Sin 2010; 62 (6): 524-528 (in Chinese with English abstract).