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[“Waste gas is not waste”: advance in the research of hydrogen sulfide.] [Ariticle in Chinese]

JIN Hong-Fang, DU Jun-Bao, TANG CHAO-SHU

Department of Pediatrics, Peking University First Hospital, Beijing 100034, China； Peking University Health Science Center, Beijing 100191, China

Abstract

The discovery of endogenous gasotransmitters puts forwards a new concept, “waste gas is not waste”. Hydrogen sulfide(H2S) is considered as a new member of gasotransmitter family, following nitric oxide (NO) and carbon monoxide (CO). Recently, theunderstanding of H2S biological effect and its mechanisms has been deepened, especially the pathophysiological significance of H2S inthe various diseases such as cardiovascular diseases, neurological diseases, respiratory diseases, endocrine diseases, etc. This articlereviews recent progress of basic, clinical and pharmacological researches related to endogenous H2S, including the regulatory effects ofH2S on the cell proliferation, apoptosis, inflammation, angiogenesis and ion channels, the role of endogenous H2S pathway in thepathogenesis of various diseases, as well as the study of the H2S donor and H2S-related drugs.

Key words: hydrogen sulfide; proliferation; apoptosis; inflammation; angiogenesis; ion channel

Received: 2010-08-29　　Accepted: 2010-10-09

Corresponding author: 金红芳　　E-mail: jinhongfang51@126.com

Citing This Article：

JIN Hong-Fang, DU Jun-Bao, TANG CHAO-SHU. [“Waste gas is not waste”: advance in the research of hydrogen sulfide.] [Ariticle in Chinese] . Acta Physiol Sin 2010; 62 (6): 495-504 (in Chinese with English abstract).