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[Autophagy and hypoxic ischemic brain injuries.] [Article in Chinese]

LI Yong-Qiang, FU Su, WANG Lai, LIU Bin, SHI Zhen-Yu^*, DENG Jin-Bo^*

Institute of Neurobiology, Nursing College, Henan University, Kaifeng 475004, China

Abstract

Autophagy is a highly evolutionarily conserved physiological mechanism of organism, including several stages such as autophagosomes formation, the fusion of lysosomes and autophagosomes, and autophagosomes degradation. In physiological conditions, autophagy is responsible for clearing the spoiled organelles and long-lived proteins to maintain the homeostasis of cells and organism. Meanwhile, autophagy is also involved in the formation and development of diseases, but the mechanism has not been confirmed yet. The relationship between autophagy and hypoxic ischemic brain injuries represented by stroke is a research hotpot in recent years, but there is no clear conclusion about autophagy’s role and mechanism in hypoxic ischemic brain injuries. We reviewed the activation, function and mechanism of autophagy in hypoxic ischemic brain injuries, in order to provide some perspectives on these researches.

Key words: autophagy; hypoxia and ischemia; oxidative stress response; apoptosis

Received: 2016-11-24　　Accepted: 2017-03-14

Corresponding author: 石贞玉,邓锦波　　E-mail: henu_szy@foxmail.com, jinbo_deng@henu.edu.cn

Citing This Article：

LI Yong-Qiang, FU Su, WANG Lai, LIU Bin, SHI Zhen-Yu, DENG Jin-Bo. [Autophagy and hypoxic ischemic brain injuries.] [Article in Chinese]. Acta Physiol Sin 2017; 69 (3): 316-324 (in Chinese with English abstract).