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[Research progress of Krüppel-like factor 7.] [Article in Chinese]

CHEN Yue-Chan, WEI Hong, ZHANG Zhi-Wei

Department of Basic Medicine, School of Medicine, Shihezi University； Office of Scientific Research, The First Affiliated Hospital of School of Medicine, Shihezi University, Shihezi 832000, China

Abstract

Krüppel-like factor 7 (KLF7), a member of Krüppel-like transcription factors (KLFs), also known as ubiquitous Krüppel- like factor (UKLF), is ubiquitously expressed in various tissues of adult human beings. Genetics reports showed that the genetic polymorphism of KLF7 is associated with obesity, type 2 diabetes, mental development in human beings; and KLF7 methylation is associated with the development of diffuse gastric cancer (gastric adenocarcinoma). In addition, some genomics reports suggested that KLF7 is one of the key transcription factors in the regulatory networks of serum markers change during the cardiovascular disease. The function studies showed that KLF7 is involved in the regulation of the development and function of the nervous system and adipose tissue, type 2 diabetes, blood diseases, as well as pluripotent cells maintenance. This review summarizes the research progress of KLF7 in genetic characteristics, protein structure and gene function.

Key words: Krüppel-like factor 7; genetic association; molecular structure; gene function

Received: 2016-05-02　　Accepted: 2016-06-29

Corresponding author: 张志威　　E-mail: zzwneau@163.com

Citing This Article：

CHEN Yue-Chan, WEI Hong, ZHANG Zhi-Wei. [Research progress of Krüppel-like factor 7.] [Article in Chinese]. Acta Physiol Sin 2016; 68 (6): 809-815 (in Chinese with English abstract).