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[Research progress of neuregulin 4 biological function.] [Article in Chinese]

Yang Fan, LI Xiao-Nan^*

Department of Child Health Care, Children’s Hospital of Nanjing Medical University, Nanjing 210008, China

Abstract

Neuregulin 4 (NRG4) is a kind of protein containing epidermal growth factor (EGF)-like domains, mainly expressed and secreted by brown adipocytes. It specifically activates EGF receptor ErbB4 (v-erb-b2 avian erythroblastic leukemia viral oncogene homolog 4) to stimulate cell proliferation, inhibit apoptosis and improve energy metabolism of cells. Increasing evidence has shown that NRG4 plays an important role in epithelial cell-related diseases, cardiovascular diseases, tumors and glycolipid metabolic diseases, and therefore it could be a potential therapeutic target of some diseases.

Key words: neuregulin 4; ErbB4; biological function

Received: 2016-09-05　　Accepted: 2017-02-22

Corresponding author: 李晓南　　E-mail: xnli@njmu.edu.cn

Citing This Article：

Yang Fan, LI Xiao-Nan. [Research progress of neuregulin 4 biological function.] [Article in Chinese]. Acta Physiol Sin 2017; 69 (3): 351-356 (in Chinese with English abstract).