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[An overview on autophagy in neural stem cells.] [Article in Chinese]

JIAO Qian, DU Xi-Xun, XIE Jun-Xia, JIANG Hong^*

State Key Disciplines: Physiology, Medical College of Qingdao University, Qingdao, 266071, China

Abstract

Neural stem cells (NSCs) offer great promise for the treatment of multiple neurodegenerative diseases. However, the survival and differentiation rates of grafted cells in the host brain need to be enhanced. In this regard, understanding of the underlying mechanism of NSCs survival and death is of great importance for the implications of stem cell-based therapeutic application in the treatments of neurological disorders. Autophagy is a conserved proteolytic mechanism required for maintaining cellular homeostasis, which can affect NSCs fate through regulating their biological behaviors, such as survival and proliferation. In this mini-review, we will summarize the effects of autophagy on NSCs fate including survival, apoptosis, proliferation and differentiation, as well as the underlying mechanisms.

Key words: autophagy; neural stem cells; apoptosis; proliferation; differentiation

Received: 2016-02-25　　Accepted: 2016-04-15

Corresponding author: 姜宏　　E-mail: hongjiang@qdu.edu.cn

Citing This Article：

JIAO Qian, DU Xi-Xun, XIE Jun-Xia, JIANG Hong. [An overview on autophagy in neural stem cells.] [Article in Chinese]. Acta Physiol Sin 2016; 68 (5): 649-654 (in Chinese with English abstract).